Endocrine Abstracts

Neurotensin is expressed throughout the gastrointestinal tract and acts as a gut hormone. Recent work has established neurotensin modulates lipid absorption at the gastrointestinal lumen, but its role in the control of glucose homeostasis remains unclear. Neurotensin acts via three receptors, including the NtsR1 and is endogenously released following the ingestion of olive oil. Previous work in our group has identified that neurotensin acutely improves glucose tolerance in bot...

NHS England has established several Complications from Excess Weight (CEW) services. Despite physical activity (PA) being an integral part of successful weight management programmes, the capacity to offer an effective PA program within CEW services could be limited by resources. The aim of the study was to assess the feasibility of embedding an exercise specialist led, mobile health (mHealth) technology supported, PA and exercise intervention (MOTIVATE-CEW) to a CEW service. A...

Background: While there have been major advances in the care of neuroendocrine tumors (NETs), there is still no widely adopted therapeutic sequencing in metastatic NETs. The roles and benefits of locoregional treatments need reassessment, in order to define a modern therapeutic algorithm. We examined contemporary short-term outcomes of liver-directed therapy for metastatic NETs.Methods: We conducted a population-based retrospective cohort study of patien...

Background: While the epidemiology of overall and gastrointestinal neuroendocrine neoplasms (NENs) has been reported, data specific to lung NENs remain scarce. Such understanding is crucial in designing tailored strategies to improve care and outcomes. We examined the incidence, overall survival (OS), and disease-specific death (DS-deaths) for lung NENs.Methods: We conducted a population-based retrospective cohort study of adult patients with incident lu...

Aim: To present a clinical case of reversible hypopituitarism due to hypophysitis developed after COVID-19 infection.Materials and methods: A patient with residual clinical manifestations of hypopituitarism underwent clinical evaluation at the time of symptoms of hypopituitarism and in follow-up. Morning serum cortisol (171-536 nmol/l) was measured by electrochemiluminescence immunoassay. Morning ACTH (7.2-63.3 pg/ml), prolactin (66-436 mU/l), TSH (0.25-...

Autoimmune thyroid disease is the common autoimmune disorders. It is more commonly in women. 2% to 4% of women and up to 1% of men are affected worldwide The prevalence increases with advancing age. Detection and quantification of the antibody titers help in establishing an autoimmune etiology.Objectives: We study the prevalence of thyroid hormone dysfunction especially TSH and positive anti-TPO antibody titers in patients suspect for thyroid-related dis...

Objective: To evaluate the efficacy, safety and to determine the criteria for the glucocorticoid therapy scheme: intravenous pulse therapy followed by tablet form in prolonged regime in the treatment of active phase of endocrine ophthalmopathy (EOP).Materials and methods: 28 patients of both sexes (52 eyes) with endocrine ophthalmopathy in the active phase were included in the study. The average age – 43.4±10.6 years. The duration of the diseas...

Tyrosine kinase inhibitors (TKIs) are relatively new therapy drugs used for the treatment of metastatic cancers including Renal cell carcinoma (RCC), gastrointestinal stromal tumours, thyroid and neuroendocrine tumours. They block vascular endothelial growth factor and other growth factors Thyroid dysfunction is often a side effect of this treatment. A close monitoring of thyroid hormone levels is a necessity.We have a case of a 69-year-old lady with RCC...

Introduction: Tertiary hyperparathyroidism (THPT) develops for the patients with chronic kidney diseases undergoes program hemodialysis. THPT is seen in patients with long-term secondary hyperparathyroidism which eventually leads to hyperplasia of the parathyroid glands (PTG) then it leads to adenomatous transformation and autonomization of the PTG.The purpose of the study is the choice of rational diagnostic and treatment algorithm for...

Introduction: Pseudohypoparathyroidism (PHP) is an orphan disease caused by a mutation in the GNAS gene encoding the α-subunit of G-protein. PHP is characterized by multihormonal resistance. A correlation between the genotype and phenotype of patients with GNAS mutations hasn’t yet been described.Clinical Case: Patient T., 19 years old male, admitted to our Centre with general weakness and overweight. Hypocalcemia, hyperphosph...